Castor Oil Ethoxylate Specifications:

Hydrogenated Castor Oil Ethoxylate Specifications

STABILITY AND STORAGE CONDITIONS
DEV INTERNATIONAL -CO-35 forms stable solutions in many organic solvents such as chloroform, ethanol and propan-2-ol; it also forms clear, stable, aqueous solutions. DEV INTERNATIONAL -CO-35 is miscible with other polyoxyethylene castor oil derivatives and on heating with fatty acids, fatty alcohols and some animal and vegetable oils. Solutions of DEV INTERNATIONAL -CO-40 in aqueous alcohols are also stable.
Aqueous solutions of DEV INTERNATIONAL -CO-35 are stable in the presence of low concentrations of electrolytes such as acids or salts, with the exception of mercuric chloride.
Aqueous solutions of DEV INTERNATIONAL -CO-35 can be sterilized by autoclaving for 20 minutes at 121ͦC. In this process a product may acquire a deeper color although this has no significance for product stability. Aqueous solutions of polyoxyl castor oil can similarly be sterilized by autoclaving at 121ͦC, but this may cause a slight decrease in the pH value.
Polyoxyethylene castor oil derivatives should be stored in a well-filled, airtight container, protected from light, in a cool, dry, place.

SAFETY
Polyoxyethylene castor oil derivatives are used in a variety of oral, topical and parenteral pharmaceutical formulations.
Acute and chronic toxicity tests in animals have shown polyoxyethylene castor oil derivatives to be essentially nontoxic and nonirritant materials. However, several serious anaphylactic reactions have been observed in humans and animals following parenteral, and more rarely, oral administration of formulations containing polyoxyethylene castor oil derivatives.

HANDLING PRECAUTIONS
Observe normal precautions appropriate to the circumstances and quantity of material handled. Eye protection and gloves are recommended.
Applications in Pharmaceutical Formulation or Technology
Polyoxyethylene castor oil derivatives are nonionic surfactants used in oral, topical and parenteral pharmaceutical formulations. They are also used in cosmetics animal feeds and Textile.
DEV INTERNATIONAL -CO-35 is mainly used as an emulsifing and solubilizing agent, and is particularly suitable for the production of aqueous liquid preparations containing volatile oils, fat-soluble vitamins and other hydrophobic substances.
DEV INTERNATIONAL -CO-35 has also been used as a solvent in proprietary injections of diazepam, propanidid and alfaxalone with alfadolone acetate. DEV INTERNATIONAL -CO-35 is also used in the production of glycerin suppositories.
In veterinary practice, DEV INTERNATIONAL -CO-35 can be used to emulsify cod liver oil, and oils and fats incorporated into animal feeding stuffs.
In cosmetics, DEV INTERNATIONAL -CO-35 is mainly used as a solubilizing agent for perfume bases and volatile oils in vehicles containing 30-50% v/v alcohol (ethanol or propan-2-ol). In hand lotions it can be used to replace castor oil.
DEV INTERNATIONAL -CO-40 may be used in preference to DEV INTERNATIONAL -CO-35 in oral formulations since it is almost tasteless. In aqueous alcoholic or completely aqueous solutions, DEV INTERNATIONAL - CO-40 can be used to solubilize vitamins, essential oils and certain drugs. Other materials which can be solubilized are, alfadolone, alfaxalone, hexacholrophane, hexetidine, methotrimeprazine, miconazole, propanidid, and thiopentone.
In aerosol vehicles which include water, the addition of DEV INTERNATIONAL -CO-40 improves the solubility of the propellant in the aqueous phase. This enhancement applies both to dichlorodifluoromethane and to propane/butane mixtures.
Foam formation in aqueous ethanol solutions containing DEV INTERNATIONAL -CO-40 can be suppressed by the addition of small amounts of polypropylene glycol 2000.
DEV INTERNATIONAL -CO-40 is also used as an emulsifier of fatty acids and alcohols.

FUNCTIONAL CATEGORY
Emulsifier, Co-emulsifier, Dispersant, Solubilizer, Lubricant, Anti stant, Emclient Wetting agent, Scouring agent, Deformer, Softener, Lubricant, Viscosity control Agent, Dying Assistant Dye Carrier, Levelling agent, Stabilizer, Penetrant